2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-114976
    S-Allylmercapturic acid
    S-Allylmercapturic acid is a biomarker of food intake (BFIs) for garlic consumption.
    S-Allylmercapturic acid
  • HY-119696S
    MTIC-d3
    MTIC-d3 is deuterium labeled MTIC. MTIC is the active metabolite of Temozolomide (TMZ). MITC has lower bioavailability in the brain compared with TMZ, because the agent’s permeability through biological barriers and tumor cell membranes affects bioavailability. MITC exhibits low affinity to biological membrane[1].
    MTIC-d<sub>3</sub>
  • HY-126852
    4-Hydroxy Atorvastatin lactone
    4-Hydroxy Atorvastatin lactone is a metabolite of Atorvastatin (HY-B0589). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids.
    4-Hydroxy Atorvastatin lactone
  • HY-125446S
    2-Hydroxymethyl olanzapine-d3
    2-Hydroxymethyl olanzapine-d3 (LY-290411-d3) is a deuterium labeled 2-Hydroxymethyl olanzapine. 2-Hydroxymethyl olanzapine is a metabolite of Olanzapine..
    2-Hydroxymethyl olanzapine-d<sub>3</sub>
  • HY-12784AS
    Cycloguanil-d4 hydrochloride
    Cycloguanil-d4 (hydrochloride) is the deuterium labeled Cycloguanil hydrochloride. Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1].
    Cycloguanil-d<sub>4</sub> hydrochloride
  • HY-135387
    4-Desmethyl Istradefylline
    4-Desmethyl Istradefylline is a metabolite of Istradefylline. 4-Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist with Ki of 2.2 nM in experimental models of Parkinson's disease.
    4-Desmethyl Istradefylline
  • HY-N3059R
    Pinostilbene (Standard)
    Pinostilbene (Standard) is the analytical standard of Pinostilbene. This product is intended for research and analytical applications. Pinostilbene (trans-Pinostilbene) is a major metabolite of Pterostilbene. Pinostilbene exhibits inhibitory effects on colon cancer cells.
    Pinostilbene (Standard)
  • HY-W700643
    Di-N-desethyl amiodarone hydrochloride
    Di-N-desethyl Amiodarone hydrochloride is a metabolite of Amiodarone (HY-14187). Di-N-desethyl Amiodarone hydrochloride is a strong inhibitor of the respiratory chain.
    Di-N-desethyl amiodarone hydrochloride
  • HY-121745
    Phosmet oxon
    Phosmet oxon (Imidoxon) is a main and toxic metabolite of phosmet. Phosmet is a cholinesterase inhibitor insecticide used on pome and stone fruits.
    Phosmet oxon
  • HY-135910R
    3,4-Dehydro Cilostazol (Standard)
    3,4-Dehydro Cilostazol (Standard) is the analytical standard of 3,4-Dehydro Cilostazol. This product is intended for research and analytical applications. 3,4-Dehydro Cilostazol (OPC-13015) is an active metabolite of Cilostazol (CLZ; HY-17464). 3,4-Dehydro Cilostazol is used for pharmacokinetic study.
    3,4-Dehydro Cilostazol (Standard)
  • HY-W336012S
    Metoprolol EP impurity O-d7 hydrochloride
    Metoprolol EP impurity O-d7 (hydrochloride) is the deuterium labeled 3,3'-(Isopropylazanediyl)bis(1-(4-(2-methoxyethyl)phenoxy)propan-2-ol)[1].
    Metoprolol EP impurity O-d<sub>7</sub> hydrochloride
  • HY-143951S
    Disulfiram impurity 1-d10
    Disulfiram impurity 1-d10 is the deuterium labeled Disulfiram impurity 1[1].
    Disulfiram impurity 1-d<sub>10</sub>
  • HY-B0300S
    Penicillamine-d3
    Penicillamine-d3 is the deuterium labeled Penicillamine. Penicillamine (D-(-)-Penicillamine) is the most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
    Penicillamine-d<sub>3</sub>
  • HY-143974S
    Imiquimod impurity 1-d6
    Imiquimod impurity 1-d6 is the deuterium labeled Imiquimod impurity 1[1].
    Imiquimod impurity 1-d<sub>6</sub>
  • HY-135373
    Desfluoro-atorvastatin
    Desfluoro-atorvastatin is an impurity of Atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids.
    Desfluoro-atorvastatin
  • HY-111742
    Bifenazate-diazene
    Bifenazate-diazene is a major degradation product of Bifenazate. Bifenazate is a selective carbazate acaricide and an insecticide.
    Bifenazate-diazene
  • HY-78846
    2R,4R-Sacubitril
    		98.66%
    2R,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.
    2R,4R-Sacubitril
  • HY-135334S
    ACP-5862-d4
    ACP-5862-d4 is deuterium labeled ACP-5862. ACP-5862 is a major active, circulating, pyrrolidine ring-opened metabolite of Acalabrutinib with an IC50 of 5.0 nM for Bruton tyrosine kinase (BTK). ACP‐5862 is a weak time‐dependent inactivator of CYP3A4 and CYP2C8. Acalabrutinib is an orally active, irreversible, and highly selective BTK inhibitor, with an IC50 of 3 nM and EC50 of 8 nM[1][2].
    ACP-5862-d<sub>4</sub>
  • HY-129491S
    O-Desmethyl Midostaurin-d5
    O-Desmethyl Midostaurin-d5 is a deuterium labeled O-Desmethyl PKC412. O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism[1].
    O-Desmethyl Midostaurin-d<sub>5</sub>
  • HY-G0016
    N-Acetyl dapsone
    N-Acetyl dapsone (MADDS) is the major metabolite of Dapsone (HY-B0688). Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities.
    N-Acetyl dapsone
Cat. No. Product Name / Synonyms Application Reactivity